For the treatment of enterobiasis, hookworm, necatorosis, ascariasis, trichocephalosis 400 mg once / day once; for the treatment of strongyloidosis, teniosis, hymenolepidosis – 400 mg 1 time / day, for 3 days; for the treatment of clonorchosis, opisthorchiasis – 400 mg 2 times / day, for 3 days; for the treatment of skin syndrome Larva Migrans – 400 mg 1 time / day, for 1-3 days; for the treatment of giardiasis for children 3-12 yEars and Nose old, 400 mg 1 time / day is prescribed for 5 days.
Composition and form of release
Active substance: carbamazepine.
Zeptol is available in the form of tablets of prolonged (long-term) action of 200 mg.
It is an antiepileptic drug. Has an antimanic, normothymic (normalizing mood) effect. The active substance activates the inhibitory GABAergic system in the brain. It also blocks potential-dependent Na-channels of nerve cell membranes, which leads to the stabilization of their function, reduces the activity of neurotransmitter acids (aspartate, glutamate), interacts with brain adenosine receptors. Increases the seizure threshold, corrects epileptic personality changes.
Zeptol is used:
at difficult and simple partial convulsive attacks (with / without loss of consciousness, with / without signs of secondary generalization);
in mixed forms of seizures;
with generalized tonic-clonic seizures;
in acute manic states;
with alcohol withdrawal syndrome;
in bipolar affective disorders (as maintenance therapy) to reduce the severity of clinical manifestations in exacerbations, as well as to prevent exacerbations;
at idiopathic neuralgia of a trigeminal nerve, neuralgia of a trigeminal nerve at a multiple sclerosis;
with idiopathic lingual-pharyngeal nerve neuralgia.
Zeptol is not used:
in case of intolerance of components;
in allergic reactions to tricyclic antidepressants in the past;
in case of AV blockade;
in the suppression of bone marrow function;
with hepatic porphyria (acute intermittent, mixed, late porphyria of the skin), including in the past;
during treatment with MAO inhibitors.
Use during pregnancy and breastfeeding
Zeptol is contraindicated during these periods.
Method of application and dose
Zeptol is administered orally (orally), regardless of food.
The selected daily dose is divided into two or three doses.
The dosage depends on the diagnosis.
Standard doses for adults: 100-200 mg once or twice a day, the dose should be increased slowly until the desired effect is achieved; the daily dose can be 800-2000 mg / day.
Standard doses for children: 100 mg / day, the dose is gradually increased (by 100 mg every week). The usual dose is 10-20 mg / kg / day (in several doses).
Symptoms: disorientation, drowsiness, decreased consciousness, agitation, blurred vision, hallucinations, coma, slurred speech, ataxia, dysarthria, nystagmus, dyskinesia, hyper / hyporeflexia, psychomotor disorders, convulsions, myomiconies, myoclonus, myoclonus, myoclonus , tachycardia, arterial hyper / hypotension, syncope, cardiac conduction disturbances, cardiac arrest, gastric retention, metabolic acidosis, rhabdomyolysis, urinary retention, oliguria / anuria, hyperhydration, fluid retention, hyponatraemia, hypertension.
Treatment: hospitalization, gastric lavage, use of sorbents, determination of carbamazepine concentration in the blood, supportive treatment, monitoring of heart function, correction of electrolyte disorders.
Changes in blood analysis: reticulocytosis, thrombocytopenia, leukopenia, eosinophilia, leukocytosis, lymphadenopathy, agranulocytosis, folic acid deficiency, aplastic anemia, erythrocyte aplasia, pancytopenia, anemia, porphyria, megaga.
Immune disorders: delayed hypersensitivity, skin rash, vasculitis, lymphadenopathy, hepatosplenomegaly, bile duct disappearance syndrome, aseptic meningitis with myoclonus, peripheral eosinophilia; angioneurotic edema, anaphylactic shock, hypogammaglobulinemia.
Endocrine disorders: edema, weight gain, decreased plasma osmolarity, hyponatremia, hyperhydration (lethargy, vomiting, headache, confusion), increased prolactin levels (galactorrhea, bone metabolism disorders, gynecomastia).
Metabolic disorders: decreased appetite, folate deficiency.
Mental disorders: hallucinations, depression, anxiety, agitation, aggression, confusion, activation of psychosis.
Neurological disorders: dizziness, cephalgia, ataxia, drowsiness, diplopia, blurred vision, involuntary movements (tremor, dystonia, fluttering tremor, tic), orofacial dyskinesia, nystagmus, eye disorders, dysarthria, slurred speech, peripheral neuroaesthesia, peripheral neuropathy paresis, muscle weakness, taste disturbance, aseptic meningitis.
Visual disorders: accommodation disorders, glaucoma, clouding of the lens, conjunctivitis.
Hearing disorders: hearing impairment, tinnitus, increased / decreased auditory sensitivity.
Cardiovascular disorders: intracardiac conduction disorders, arterial hypotension / hypertension, bradycardia, arrhythmia, syncope, congestive heart failure, circulatory collapse, exacerbation of coronary heart disease, thromboembolism, thrombophlebitis.
Respiratory disorders: shortness of breath, pneumonitis, pneumonia.
Digestive disorders: nausea, dry mouth, diarrhea / constipation, stomatitis, abdominal pain, glossitis, pancreatitis, increased gamma-glutamyltransferase, FF, transaminases, hepatitis, biliary tract syndrome, granulomatous hepatitis, jaundice.
Skin changes: allergic dermatitis, erythroderma, urticaria, exfoliative dermatitis, systemic lupus erythematosus, Stevens-Johnson syndrome, epidermal necrolysis, pruritus, photosensitivity, nodular or erythema multiforme, purpura, acne, acne, skin disorders .
Musculoskeletal disorders: muscle weakness, arthralgia, muscle spasms.
Genitourinary disorders: tubulointerstitial nephritis, renal failure, renal dysfunction (hematuria, albuminuria, oliguria, azotemia), urinary retention, increased urination, impotence, spermatogenesis disorders, erectile dysfunction.
General disorders: weakness.
Conditions and terms of storage
Store Zeptol at 15–25 ° C for no more than three years.