Zercalin (klindamitsin) solution for external use 1% 30 ml. vial №1


Manufacturer: Croatia

This pharmaceutical drug refers to drugs used for the local treatment of acne.


Zercalin (klindamitsin) solution for external use 1% 30 ml. vial №1


active ingredient: clindamycin;

1 ml of solution contains clindamycin – 10 mg, in the form of clindamycin hydrochloride;

excipients: ethanol 96%, propylene glycol, purified water.

Dosage form

Skin solution.

Basic physical and chemical properties: colorless transparent liquid with an ethanol smell.

Pharmacological group

Antimicrobial agents for the treatment of acne. Clindamycin.

ATX code D10A F01.

Pharmacological properties

This pharmaceutical drug refers to drugs used for the local treatment of acne.
The main active ingredient is clindamycin. Due to clindamycin phosphate – a semi-synthetic antibacterial drug, a derivative of lincamycin, an inhibitor of protein synthesis of pathological bacteria – the processes of peptide chain formation are inhibited at their initial stage.
Has antibacterial activity against more gram-positive microorganisms. Anaerobes and simple microorganisms are also exposed to the drug. Fungi and viruses cannot be treated with this drug.
Clindamycin has the ability to inhibit (inhibit) the activity of cultures of bacteria “propionibacterium acne”. Suppression of the growth of these bacteria inside the sebaceous glands and follicles reduces the concentration of FFA in the sebum.
Also has an anti-inflammatory effect.
It should be noted that in the process of clinical use of the drug was found cross-addiction (resistance) of clindamycin and erythromycin.


This drug is used to treat acne or acne.
It is intended for local application.


The drug in question is contraindicated in cases where the patient has a pronounced hypersensitivity (allergy) to the main or to one of the auxiliary components.
Contraindicated in ulcerative colitis and colitis, which are caused by antibiotics.
The risks of hypersensitivity reactions when using this drug increase with the prior use of lotions and other cosmetics containing alcohol.
Use with caution at the same time with agents that contain sulfur, resorcinol or salicylic acid compounds.
Clindamycin is able to block neuromuscular transmission. As a consequence, it should be used with caution in the treatment of those patients who are being treated with other neuromuscular drugs due to the likelihood of enhancing their effect.
The drug should not be applied to areas of skin affected by eczema, sunburn, lamp ultraviolet radiation.
Not used in pediatrics.

Method of application and dose

It is applied topically – the solution is applied with a cotton swab on clean, dry skin, in places where there are rashes. Application is usually done in the morning and evening – twice a day.
The therapeutic effect of the application is observed in 8-12 weeks after the start of treatment.
The duration of treatment depends on the individual response of the drug to the body and is determined by the attending physician.
Avoid getting the gel in the eyes, on the lips, other mucous surfaces. If the drug accidentally gets on the mucous membranes, you need to wash it off as soon as possible with plenty of warm water.
The use of drying, abrasive, alcohol-containing cosmetics can cause skin irritation.


Cases of overdose are extremely rare. However, excessive application of the drug can lead to redness and peeling of the skin, the manifestation of systemic side effects.
These symptoms are reversible. In this case, symptomatic therapy is recommended.

Side effects

Possible side effects:

  •  intensification of acne in the first days of treatment;
  •  irritation of the skin at the application site;
  •  burning sensation in the eyes;
  •  abdominal pain, disorders of the gastrointestinal tract;
  •  folliculitis, which is caused by gram-negative bacteria;
  •  skin irritation, peeling, contact dermatitis, oily skin, allergic urticaria;
  •  dryness, erythema;
  •  diarrhea, colitis.

These side effects may persist for several weeks after treatment.