Infections caused by microorganisms sensitive to azithromycin: infections of ENT organs (bacterial pharyngitis / tonsillitis, sinusitis, otitis media); respiratory tract infections (bacterial bronchitis, non-hospital pneumonia); skin and soft tissue infections: migratory erythema (initial Lyme disease), erysipelas, impetigo, secondary pyodermatosis; acne vulgaris (acne common) of moderate severity; sexually transmitted infections: uncomplicated ingenious infections caused by Chlamydia trachomatis.
Zitrox (azithromycin) coated tablets 250 mg. №6
active substance: azithromycin;
1 tablet contains azithromycin dihydrate equivalent to azithromycin 250 mg or 500 mg;
Excipients: calcium hydrogen phosphate, pregelatinized starch, crospovidone, polysorbate 80, colloidal anhydrous silica, microcrystalline cellulose, sodium lauryl sulfate, talc, magnesium stearate, hypromellose, titanium dioxide (E 171).
Basic physical and chemical properties:
- 250 mg tablets: white, biconvex, capsule-shaped, coated, smooth on both sides;
- 500 mg tablets: White, biconvex, capsule-shaped, film-coated tablets with a fracture line on one side and smooth tablets on the other.
Antibacterial agents for systemic use. Macrolides, lincosamides and streptogramins. Azithromycin. ATX code J01F A10.
Azithromycin is a macrolide antibiotic that belongs to the group of azalides. The molecule is formed by introducing a nitrogen atom into the lactone ring of erythromycin A. The mechanism of action of azithromycin is to inhibit bacterial protein synthesis by binding to the 50 S-subunit of ribosomes and inhibiting peptide translocation.
Zitrox coated tablets is indicated for infections caused by microorganisms sensitive to this antibiotic:
- otorhinolaryngological (sinusitis, otitis media, sore throat, pharyngitis);
- respiratory tract (bronchitis, pneumonia, including atypical, pleural empyema, lung abscess);
- soft tissues, skin (pyoderma, erysipelas, acne, impetigo, abscess, boils, phlegmon, secondary infected dermatoses);
- urogenital system (gonorrheal or non-gonorrheal urethritis, cervicitis, cystitis, endometritis, prostatitis, pyelonephritis);
- at the initial stage of Lyme disease (tick-borne borreliosis) – erythema migrans.
Zitrox coated tablets is not used:
- at intolerance of components of drug;
- with allergies to macrolides in the past;
- with severe hepatic / renal impairment;
- at a body weight not exceeding 45 kg.
Use during pregnancy and breastfeeding
Azithromycin penetrates the placental barrier, so administration to pregnant women is permissible only in cases where the benefits to the mother outweigh the risks to the fetus.
If treatment is required during lactation, cessation of breastfeeding is indicated.
Method of application and dose
Zitrox coated tablets powder is administered orally.
The doctor sets the dose taking into account the severity of the disease, the nosological form, the sensitivity of the pathogen.
The standard dose for adults is 250-1000 mg once a day, for children – 5-10 mg / kg / day.
The duration of treatment is individual, depends on the demonstrated therapeutic effect, the severity of the infectious process. Usually 2-5 days.
Symptoms: diarrhea, temporary hearing loss, vomiting.
In case of overdose, gastric lavage, administration of enterosorbents, symptomatic therapy are indicated.
- neurological disorders: cephalgia, vertigo, paresthesia, agitation, fatigue, drowsiness, tinnitus, hyperkinesia, hearing impairment (reversible) up to deafness, anxiety, conjunctivitis, nervousness, sleep disturbance;
- cardiovascular disorders: chest pain, palpitations;
- digestive disorders nausea, flatulence, diarrhea, abdominal pain, cholestasis, jaundice, discoloration of the tongue, constipation, pseudomembranous colitis, pancreatitis, loss of appetite, liver failure, liver necrosis, candidiasis of the mucous membranes of the mouth, active hypertension, gastritis, gastritis bilirubin;
- genitourinary disorders: candidal colpitis, nephritis;
- allergic reactions: anaphylactic shock, itching, hives, rash, Quincke’s edema (angioneurotic).